Welcome to International Network for Natural Sciences

Paper Details

Research Paper | March 5, 2022

| Download

Cord blood neuroglobin in anoxo-ischemic encephalopathy syndrome

Nnang Jean Fidèle, OvonoAbessolo Félix, Minko Julienne, Allogho Michèle, Ngou-Milama Edouard

Key Words:

Int. J. Biosci.13(2), 126-132, August 2018

DOI: http://dx.doi.org/10.12692/ijb/20.2.1-20

Certification: IJB 2018 [Generate Certificate]


Anoxo-ischemic encephalopathy syndrome is frequent in neonates. This syndrome would induced anaerobic metabolism and the synthesis of neuroglobin, protein designated to protect neurons. Our aim was to investigate the relationship among parameters of diagnosis and prognosis of anoxo-ischemic encephalopathy and neuroglobin concentration in neonatal cord blood. This observational, prospective and case-control study took place from April 1, 2017 to April 30, 2018. It involved 51 newborns with anoxo-ischemic encephalopathy and 51 controls. After a clinical examination, we obtained 2 ml of umbilical venous blood sample for the determination of neuroglobin and lactates. Relationships between quantitative and qualitative variables were studied by the ANOVA test. Correlations were derived between lactate and neuroglobin. The threshold of significance was 5%. The amniotic fluid aspect was different between controls and patients (p=0.000). In the control group, the neuroglobin concentration was 3.6±1.2 ng/ml, compared to 4.1±0.8 ng/ml for anoxo-ischemic encephalopathy group (p=0.076). In addition, the lactate concentration was 1157.4±34.0 mg/dl in the control group compared to 1552.7 mg/dl for the anoxo-ischemic encephalopathy group (p=0.005). If the concentration of neuroglobin was related to the appearance of the amniotic fluid (p=0.0107), it was not, however, correlated with the lactate concentration (r=0.037, p=0.737). This study shows that the concentration of neuroglobin in cord blood does not differ between children with anoxo-ischemic encephalopathy and control ones. Therefore, this is not a valuable for the diagnosis of anoxo-ischemic encephalopathy syndrome.


Copyright © 2021
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Cord blood neuroglobin in anoxo-ischemic encephalopathy syndrome

Akerman F, Mokarami P, Kallen K, Oloffson P. 2018. The small-for-gestational-age fetus has an intact ability to develop lacticemia when exposed to hypoxia: a retrospective comparative register study. Journal of Maternal-Fetal and Neonatal Medicine 31(10), 1290-7. http://dx.doi.org/10.1080/14757058.2017.1315098.

Apgar V. 1953. A proposal for a new method of evaluation of the newborn infant. Current Researches in Anesthesia and Analgesia 32(4), 260–7.

Ascenzi P, di Masi A, Leboffe L, Fiocchetti M, Nuzzo MT, Brunori M, Marino M. 2016. Neuroglobin: From structure to function in health and disease. Molecular Aspects of Medicine 52, 1-48. http://dx.doi.org/101016/j.mam.2016.10.004.

Association Médicale Mondiale. 2013. Principes éthiques applicables à la recherche médicale impliquant des êtres humains; Helsinki [En ligne]. Disponible sur l’URL: [consultée le 02/02/2017]. http://www.wma.net/fr/

Baez E, Echeverria V, Cabezas R, Avila- Rodriguez M, Garcia-Segura LM, Barreto GE. 2016. Protectionbyneuroglobinexpression in brainpathologies. Frontiers in Neurology 7, 146. http://dx.doi.org/10.3389/fneur.2016.00146.

Boog G. 2001. Souffrancefoetaleaigue. Journal de Gynécologie, Obstétrique et Biologie de la Reproduction 30, 393-432.

Chiang MC, Lien R, Chu S-M, Yang P-H, Lin J-I, Hsu J-F, Fu RH, Lin KL. 2016. Serum lactate, Brain magnetic resonance imaging and outcome of neonatal hypoxic ischemic encephalopathy, after therapeutic hypothermia. Pediatrics and Neonatology 57(1), 35-40. http://dx.doi.org/10.1016/j.pedneo.2015.04.008.

Einikyte R, Snieckuviene V, Ramasanskaite D, Panaviene J, Paliulyte V, Opolskiane G, Kazenaite E. 2017. The comparison of umbilical cord arterial blood lactate and pH values for predicting short-term neonatal outcomes. Taiwanese Journal of Obstetrics and Gynecology 56(6), 745-9. http://dx.doi.org/10.1016/j.tjog.2017.10.007.

Gjerris AC, Staer-Jensen J, Jorgensen JS, Bergholt T, Nickelsen C. 2008. Umbilical cord blood lactate: a valuable tool in the assessment of fetal metabolic acidosis. European Journal of Obstetrics, Gynecology and Reproductive Biology 139(1), 16-20.

Jin K, Mao Y, Mao X, Xie L, Greenberg DA. 2010. Neuroglobin expression inischemic stroke. Stroke 41(3), 557-9. http://dx.doi.org/10.1161/STROKEAHA.109.567149.

Karlsson M, Wiberg-Itzel E, Chakkarapani E, Blennow M, Winbladh B, Thoresen M. 2010. Lactate deshydrogenase predicts hypoxic-ischaemic encephalopathy in newborn infants: a preliminary study. Acta Paediatrica 9, 1139-4. http://dx.doi.org/10.1111/j.1651-2227.2010.01802.x.

Li SQ, Li WB, Zhang M, Wu YZ, Hu YY. 2013. The role of neuroglobin in the neuroprotection of limb ischemic preconditioning in rats.Molecular Neurobiology 47(1), 197-208. http://dx.doi.org/10.1007/s12035012-8373-7.

Minko JL, Meye JF, Thiane EHO, Owono MM, Makaya A. 2004. La souffrance fœtale aigue : expérience du service de néonatalogie du Centre Hospitalier Universitaire de Libreville. Médecined’ Afrique Noire 4, 227- 30.

Okoko AR, Ekouya-Bowassa G, Moyen E, Togho-Abessou LC, Atanda HL, Moyen G. 2016. Asphyxie périnatale au Centre Hospitalier et Universitaire de Brazaville. Journal de Pédiatrie et de Puériculture 29, 295 – 300.

Ragy M, Ali F, Ramzy MM. 2016. Effect of Hemin  on Brain alterations and neuroglobin expression in water immersion restraint stressed rats. Scientifica (Cairo) 2016, 7825396. http://dx.doi.org/10.1155/2016/7825396.

Tiwari PB, Chapagain PP, Uren A. 2018. Investigating molecular interactions between oxidized neuroglobin and cytochrome c. Scientific Reports 8(1), 10557. http://dx.doi.org/10.1038/s41598-018-28836-6.

Van Acker ZP, Luyckx E, Dewilde S. 2018. Neuroglobin expression in the brain: a story of tissue homeostasis preservation. Molecular Neurobiology. http://dx.doi.org/10.1007/s12035-018-1212-8.

Van Leuven W, Van Dam D, Moens L, De Deyn PP, Dewilde S. 2013. A behavioural study of neuroglobin-overexpressing mice under normoxic and hypoxic conditions. Biochimica et Biophysica Acta 1834, 1764–71. http://dx.doi.org/10.1016/j.bbapap.2013.04.015.

Xie LK, Yan SH. 2016. Brain globins in physiology and physiopathology. Medical Gas Reseach 6(3), 154-63.

Tian SF, Yang HH, Xiao DP, Huang YJ, He GY, Ma HR, Xia F, Shi XC. 2013. Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model. Journal of Biological Chemistry 288(22), 15988-6003. http://dx.doi.org/10.1074/jbc.M112.428789.

Yu Z, Liu N, Liu J. 2012. Neuroglobin a novel target for endogenous neuroprotection against stroke and neurodegenerative disorders. International Journal of Molecular Sciences 13(6), 6995-7014. http://dx.doi.org/10.3390/ijms1306695.

Zaigham M, Kallen K, Oloffson P. 2018. Assessment of lactate production as a response to sustained intra-partum hypoxia in large-for-gestational-age newborns. Acta Obstetricia et Gynecologica Scandinavica. http://dx.doi.org/10.1111/aogs.13384.

Zupan Simunek V. 2008. Définition de l’asphyxie intrapartum et conséquences sur le devenir. Journal de Gynécologie, Obstétrique et Biologie de la Reproduction 37S, S7- S15. http://dx.doi.org/10.1016/j.jgyn.2007.11.006.


Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background